Review this page on SARS-CoV-2 / Covid-19 or vaccination research that didn’t fit neatly into the other categories:
IMPORTANT (Published 2020 – Mistrust in doctors) – Mistrust in Science — A Threat to the Patient–Physician Relationship https://www.nejm.org/doi/10.1056/NEJMms1813043 Non paywall version https://pdfs.semanticscholar.org/59ca/08c37720c6fbd0ad9202c0e568fd8c0df264.pdf
VERY IMPORTANT (Complete view from trials to adverse) McCullough paper – COVID-19 mRNA Vaccines: Lessons Learned from the Registrational Trials and Global Vaccination Campaign
IMPORTANT (Techniques that misled the public) – The pharmaceutical industry is dangerous to health. Further proof with COVID-19 https://pubmed.ncbi.nlm.nih.gov/36324959/
Background: The COVID-19 period highlights a huge problem that has been developing for decades, the control of science by industry. In the 1950s, the tobacco industry set the example, which the pharmaceutical industry followed. Since then, the latter has been regularly condemned for illegal marketing, misrepresentation of experimental results, dissimulation of information about the dangers of drugs, and considered as criminal. Therefore, this study was conducted to show that knowledge is powerfully manipulated by harmful corporations, whose goals are: 1/financial; 2/to suppress our ability to make choices to acquire global control of public health.
Methods: Pharmaceutical industry techniques for manipulating science and COVID-19 reporting were reviewed. Several sources of official documents were used: PubMed; National Institutes of Health resources; pharmaceutical companies; policy documents; national newspapers and news agencies; and books by prominent professionals (scientific and legal). A few studies have not been published in peer-reviewed journals; however, they have been conducted by reputable scientists in their respective fields.
Results: Since the beginning of COVID-19, we can list the following methods of information manipulation which have been used: falsified clinical trials and inaccessible data; fake or conflict-of-interest studies; concealment of vaccines’ short-term side effects and total lack of knowledge of the long-term effects of COVID-19 vaccination; doubtful composition of vaccines; inadequate testing methods; governments and international organizations under conflicts of interest; bribed physicians; the denigration of renowned scientists; the banning of all alternative effective treatments; unscientific and liberticidal social methods; government use of behavior modification and social engineering techniques to impose confinements, masks, and vaccine acceptance; scientific censorship by the media.
Conclusion: By supporting and selecting only the one side of science information while suppressing alternative viewpoints, and with obvious conflicts of interest revealed by this study, governments and the media constantly disinform the public. Consequently, the unscientifically validated vaccination laws, originating from industry-controlled medical science, led to the adoption of social measures for the supposed protection of the public but which became serious threats to the health and freedoms of the population.
IMPORTANT (Biological weaponisation) – Coronavirus Is a Biological Warfare Weapon https://typeset.io/papers/coronavirus-is-a-biological-warfare-weapon-4defms7bt8
IMPORTANT (Pandemic plans lead to fascism) – Pandemic preparedness and the road to international fascism https://onlinelibrary.wiley.com/doi/10.1111/ajes.12531
IMPORTANT (Fauci stating importance of gain of function benefits over potential risks) Published 2012 – Research on highly pathogenic H5N1 influenza virus: the way forward https://pubmed.ncbi.nlm.nih.gov/23047751/
IMPORTANT (Myth of “Prevents severe illness and death” analysed / debunked) – The Efficacy of COVID-19 Vaccine Boosters against Severe Illness and Deaths: Scientific Fact or Wishful Myth? https://jpands.org/vol28no1/ophir.pdf?mibextid=ykz3hl
IMPORTANT (Individuals genes affect immune response) – Genomic insights into mRNA COVID-19 vaccines efficacy: Linking genetic polymorphisms to waning immunity https://pubmed.ncbi.nlm.nih.gov/39254005/
This study found that genetic differences can affect how long vaccine protection against COVID-19 lasts. By analyzing data from 1,119 vaccinated people and their breakthrough infections, researchers identified specific genes linked to immune function that influence the likelihood of breakthrough cases. They also discovered that people with higher genetic risk scores were more prone to breakthrough infections. This suggests that understanding individual genetics could help in creating personalized vaccination strategies to improve long-term immunity.
IMPORTANT (VAEDS mechanisms) – Vaccine-associated enhanced disease in humans and animal models: Lessons and challenges for vaccine development https://www.frontiersin.org/articles/10.3389/fmicb.2022.932408/full
In a few situations, vaccine-mediated immune responses may have led to exacerbated pathology upon subsequent infection with the pathogen targeted by the vaccine. Such vaccine-associated enhanced disease (VAED) has been reported, or at least suspected, in animal models, and in a few instances in humans, for vaccine candidates against the respiratory syncytial virus (RSV), measles virus (MV), dengue virus (DENV), HIV-1, simian immunodeficiency virus (SIV), feline immunodeficiency virus (FIV), severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), and the Middle East respiratory syndrome coronavirus (MERS-CoV). Although alleviated by clinical and epidemiological evidence, a number of concerns were also initially raised concerning the short- and long-term safety of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is causing the ongoing COVID-19 pandemic. Although the mechanisms leading to this phenomenon are not yet completely understood, the individual and/or collective role of antibody-dependent enhancement (ADE), complement-dependent enhancement, and cell-dependent enhancement have been highlighted. Here, we review mechanisms that may be associated with the risk of VAED, which are important to take into consideration, both in the assessment of vaccine safety and in finding ways to define models and immunization strategies that can alleviate such concerns.
IMPORTANT (Mechanical ventilation killed 25% of ICU patients) – Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area https://jamanetwork.com/journals/jama/fullarticle/2765184
IMPORTANT (Vaccines are gene therapy) – mRNA: Vaccine or Gene Therapy? The Safety Regulatory Issues https://www.mdpi.com/1422-0067/24/13/10514
COVID-19 vaccines were developed and approved rapidly in response to the urgency created by the pandemic. No specific regulations existed at the time they were marketed. The regulatory agencies therefore adapted them as a matter of urgency. Now that the pandemic emergency has passed, it is time to consider the safety issues associated with this rapid approval. The mode of action of COVID-19 mRNA vaccines should classify them as gene therapy products (GTPs), but they have been excluded by regulatory agencies. Some of the tests they have undergone as vaccines have produced non-compliant results in terms of purity, quality and batch homogeneity. The wide and persistent biodistribution of mRNAs and their protein products, incompletely studied due to their classification as vaccines, raises safety issues. Post-marketing studies have shown that mRNA passes into breast milk and could have adverse effects on breast-fed babies. Long-term expression, integration into the genome, transmission to the germline, passage into sperm, embryo/fetal and perinatal toxicity, genotoxicity and tumorigenicity should be studied in light of the adverse events reported in pharmacovigilance databases. The potential horizontal transmission (i.e., shedding) should also have been assessed. In-depth vaccinovigilance should be carried out. We would expect these controls to be required for future mRNA vaccines developed outside the context of a pandemic.
IMPORTANT (mRNA platform novelty) – The Novelty of mRNA Viral Vaccines and Potential Harms: A Scoping Review https://www.mdpi.com/2571-8800/6/2/17
Pharmacovigilance databases are showing evidence of injury in the context of the modified COVID-19 mRNA products. According to recent publications, adverse event reports linked to the mRNA COVID-19 injections largely point to the spike protein as an aetiological agent of adverse events, but we propose that the platform itself may be culpable. To assess the safety of current and future mRNA vaccines, further analysis is needed on the risks due to the platform itself, and not specifically the expressed antigen. If harm can be exclusively and conclusively attributed to the spike protein, then it is possible that future mRNA vaccines expressing other antigens will be safe. If harms are attributable to the platform itself, then regardless of the toxicity, or lack thereof, of the antigen to be expressed, the platform may be inherently unsafe, pending modification. In this work, we examine previous studies of RNA-based delivery by a lipid nanoparticle (LNP) and break down the possible aetiological elements of harm.
VERY IMPORTANT (Past tabletop exercise for a coronavirus called SPARS) – The SPARS Pandemic 2025–2028: A Futuristic Scenario to Facilitate Medical Countermeasure Communication
IMPORTANT (Virus schematic) – Molecular Architecture of the SARS-CoV-2 Virus https://pubmed.ncbi.nlm.nih.gov/32979942/
IMPORTANT (Aluminium adjuvant harms) – Updated aluminum pharmacokinetics following infant exposures through diet and vaccination https://pubmed.ncbi.nlm.nih.gov/22001122/ – Informed Consent Action Network – How Aluminum Adjuvants In Vaccines Can Cause Autism https://icandecide.org/article/how-aluminum-adjuvants-in-vaccines-can-cause-autism/
IMPORTANT (Connection to autism) – Prenatal Exposure to COVID-19 mRNA Vaccine BNT162b2 Induces Autism-Like Behaviors in Male Neonatal Rats: Insights into WNT and BDNF Signaling Perturbations https://link.springer.com/article/10.1007/s11064-023-04089-2
Pregnant rats received the COVID-19 mRNA BNT162b2 vaccine during gestation. Subsequent evaluations on male and female offspring included autism-like behaviors, neuronal counts, and motor performance. Molecular techniques were applied to quantify WNT and m-TOR gene expressions, BDNF levels, and specific cytokines in brain tissue samples. The findings were then contextualized within the extant literature to identify potential mechanisms. Our findings reveal that the mRNA BNT162b2 vaccine significantly alters WNT gene expression and BDNF levels in both male and female rats, suggesting a profound impact on key neurodevelopmental pathways. Notably, male rats exhibited pronounced autism-like behaviors, characterized by a marked reduction in social interaction and repetitive patterns of behavior. Furthermore, there was a substantial decrease in neuronal counts in critical brain regions, indicating potential neurodegeneration or altered neurodevelopment. Male rats also demonstrated impaired motor performance, evidenced by reduced coordination and agility. Our research provides insights into the effects of the COVID-19 mRNA BNT162b2 vaccine on WNT gene expression, BDNF levels, and certain neurodevelopmental markers in a rat model.
IMPORTANT (Manufacturing questions – Process 2) – Effect of mRNA Vaccine Manufacturing Processes on Efficacy and Safety Still an Open Question https://www.bmj.com/content/378/bmj.o1731/rr-2
IMPORTANT (Batches tested by Dutch scientists show differing adverse events – Schmeling et al) – Batch-dependent safety of the BNT162b2 mRNA COVID-19 vaccine https://onlinelibrary.wiley.com/doi/10.1111/eci.13998
The total number of SAEs associated with each batch was divided by the number of doses in the batch to obtain the rate of SAEs per 1000 doses. Since the observed relationship between the numbers of SAEs and BNT162b2 vaccine doses was highly heterogeneous, conventional regression statistics were not considered to be applicable. Therefore, heterogeneity in the relationship between the numbers of SAEs and doses per vaccine batch was assessed by log-transformation followed by non-hierarchical cluster analysis and general linear model (GLM) test for differences in SAE rates between batches. Reporting of the study conforms to broad EQUATOR guidelines.3
The observed variation in SAE rates and seriousness between BTN162b2 vaccine batches in this nationwide study was contrary to the expected homogenous rate and distribution of SAEs between batches. In Denmark and other EU/EEA countries, vaccine quality is monitored according to Official Control Authority Batch Release (OCABR) guidelines and to our knowledge, potential differences in BNT162b2 vaccine batch clinical safety or effectiveness have not been reported previously, for example in pre-authorization trials and subsequent population-based studies.4, 5 Such effects may be easier to detect in small countries like Denmark where BNT162b2 vaccines during the study period were generally provided in several smaller batches. Also, regulatory monitoring and scientific interest in COVID-19 vaccine safety have primarily focused on serious adverse events, for example myocarditis.6 In any case, identification of such effects evidently requires that observed adverse events are linked with the respective individual batch labels and sizes (dose numbers). Previously, variation in the production (culture growth) of the Bacille Calmette-Guérin vaccine has been shown to influence important immunological effects of this vaccine,7 and two cases of myocarditis have been reported in two young males after receiving mRNA-1273 COVID-19 vaccine (Moderna) from the same vaccine batch on the same day.8 Indeed, variations (batch-to-batch, vial-to-vial and even dose-to-dose) in vaccines may occur as a result of variabilities and practice breaches in, for example vaccine manufacturing, storage, transportation, clinical handling and control aspects, and in 2021, three lots of the mRNA1273 vaccine totalling more than 1.6 million doses were recalled in Japan after 39 vials of the vaccine were found to contain foreign materials.9 Leaked and contested data have also suggested that some early commercial batches of the BNT162b2 vaccine contained lower than expected levels of intact mRNA.10
IMPORTANT (Batch tests similar to Denmark above) – Reports of Batch-Dependent Suspected Adverse Events of the BNT162b2 mRNA COVID-19 Vaccine: Comparison of Results from Denmark and Sweden https://www.mdpi.com/1648-9144/60/8/1343
Results: Significant batch-dependent heterogeneity was found in the number of SAEs per 1000 doses for both countries, with batches associated with high SAE rates detected in the early phase of the vaccination campaign and positive correlations observed between the two countries for the severity of SAEs from vaccine batches that they shared. Mild SAEs predominated in the batches used in the early part of the vaccination roll-out, where markedly higher SAE rates per 1000 doses in Denmark for the batches that were shared between the two countries suggested that a large proportion of these SAEs were under-reported in Sweden.
Conclusions: The batch-dependent safety signal observed in Denmark and now confirmed in Sweden suggests that early commercial batches of BNT162b2 may have differed from those used later on, and these preliminary and hypothesis-generating results warrant further study.
IMPORTANT (High viral replication error rate of the virus) – Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN https://www.pnas.org/doi/pdf/10.1073/pnas.2106379119
IMPORTANT (Severe Covid cases in males result in sperm hiding virons) – Transmission electron microscopy reveals the presence of SARS-CoV-2 in human spermatozoa associated with an ETosis-like response https://onlinelibrary.wiley.com/doi/abs/10.1111/andr.13612
IMPORTANT (Virus evolution) – Evolution of pathogen virulence https://www.embopress.org/doi/full/10.15252/embr.202357611
IMPORTANT (RBD of the viral spike) – Biophysical evolution of the receptor binding domains of SARS-CoVs https://www.biorxiv.org/content/10.1101/2023.06.13.544630v1
IMPORTANT (Journals publishing bias) – COVID-19 advocacy bias in the BMJ: meta-research evaluation https://www.medrxiv.org/content/10.1101/2024.06.12.24308823v1
Results 122 authors published more than 5 COVID-19-related items each in BMJ. Of those, 18 were leading members/signatories of aggressive measures advocacy groups publishing 231 COVID-19 related BMJ documents, 53 were editors/journalists, and 51 scientists were not identified as associated with any advocacy. Of 41 authors with >10 publications in BMJ, 8 were scientists advocating for aggressive measures, 7 were editors, 23 were journalists, and only 3 were non-advocate scientists. Some aggressive measures advocates already had strong BMJ presence pre-pandemic. During pandemic years, the studied indieSAGE/Vaccines-Plus advocates outperformed in BMJ presence leading SAGE members by 16.0-fold, UK-based GBD advocates by 64.2-fold, the most-cited scientists by 16.0-fold, and the authors who published most COVID-19 papers overall by 10.7-fold. The difference was driven mainly by short opinion pieces and analyses.
Conclusions BMJ appears to have favored and massively promoted specific COVID-19 advocacy views during the pandemic, thereby strongly biasing the scientific picture on COVID-19.
IMPORTANT – COVID UPDATE: What is the truth? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062939/
IMPORTANT – The mRNA COVID-19 vaccines: initially ineffectual, harmful now? https://www.researchgate.net/publication/369853787_The_mRNA_COVID-19_vaccines_initially_ineffectual_harmful_now
IMPORTANT (Cognitive impairment following acute Covid-19) – Post-acute COVID-19 cognitive impairment and decline uniquely associate with kynurenine pathway activation: a longitudinal observational study https://www.medrxiv.org/content/10.1101/2022.06.07.22276020v1
IMPORTANT (Fact checkers) – Characteristics of Facebook’s third-party medical fact checkers https://journals.sagepub.com/doi/full/10.1177/20552076221120318
IMPORTANT (Review of research with an Australian perspective) Peer reviewed in Journal of Clinical and Experimental Immunology Sept 2022 – COVID-19 vaccines – An Australian Review https://www.opastpublishers.com/open-access-articles/covid19-vaccinesan-australian-review.pdf Queensland University – https://espace.library.uq.edu.au/view/UQ:321d96a
Authors found:
Initial information
The mRNA vaccines were supposed to remain at the injection site and be taken up by the lymphatic system. This assumption proved to be wrong. During an autopsy of a vaccinated person that had died after mRNA vaccination it was found that the vaccine disperses rapidly from the injection site and can be found in nearly all parts of the body [1]. The mRNA is enveloped in liquid nanoparticles (LNP) containing a mixture of phospholipids, cholesterol, PEGylated lipids and cationic or ionizable lipids [2]. Research has shown that such nanoparticles can cross the blood-brain barrier [3] and the blood-placenta barrier [4], so it came as no surprise that the European Medicines Agency assessment report for the Moderna vaccine on page 47 (https://www.ema.europa.eu/en/documents/assessment-report/spikevax-previously-covid-19-vaccine-moderna-epar-public-assessment-report_en.pdf) also noted that mRNA could be detected in the brain following intramuscular administration at about 2% of the level found in plasma. In 2021 researchers from Japan reported a disproportionately high mortality due to cerebral venous sinus thrombosis and intracranial haemorrhage. Despite not being able to prove a causal link with vaccines, as no autopsies were performed, they still believed that a link with vaccination is possible and further analysis is warranted
[5].
VERY IMPORTANT (Ivermectin works) – Prophylactic administration of ivermectin attenuates SARS-CoV-2 induced disease in a Syrian Hamster Model https://www.nature.com/articles/s41429-023-00623-0
VERY IMPORTANT (HCQ Works) – Chloroquine is a potent inhibitor of SARS coronavirus infection and spread https://pubmed.ncbi.nlm.nih.gov/16115318/
VERY IMPORTANT (Live meta-analysis of HCQ) – HCQ for COVID-19 real-time analysis of all 552 studies https://c19hcq.org/meta.html
VERY IMPORTANT (Informed consent – published 2020) – Informed consent disclosure to vaccine trial subjects of risk of COVID‐19 vaccines worsening clinical disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645850/
IMPORTANT (Kostov) – Why are we vaccinating children against COVID-19? https://www.sciencedirect.com/science/article/pii/S221475002100161X#bib0030
IMPORTANT (Sudden death syndrome) – Genetic basis of sudden death after COVID-19 vaccination in Thailand https://pubmed.ncbi.nlm.nih.gov/35934244/
Expectations and Prior Experiences Associated With Adverse Effects of COVID-19 Vaccination https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2802767
VERY IMPORTANT (PCR testing not accurate, therefore original trials based on false information – 42% false discovery rate) – Evidence-Based Evaluation of PCR Diagnostics for SARS-CoV-2 and the Omicron Variants by Sanger Sequencing https://www.publichealthpolicyjournal.com/about-7
Author notes: The flaw of the RT-qPCR as a diagnostic assay is that it depends on a number, which may vary from laboratory to laboratory and from test run to test run, to distinguish between the positives and the negatives of a test result. The analyte of PCR is a segment of target DNA, the presence of which can only be verified by demonstrating its nucleotide sequence.
IMPORTANT (Constant testing might increase infection) – Rapid antigen testing for COVID-19: Decreasing diagnostic reliability, potential detrimental effects and a lack of evidence to support continued public funding of community-based testing https://www.sciencedirect.com/science/article/pii/S2666535223000976?via%3Dihub
Recent research has found multiple commonly-used rapid antigen tests to now have diagnostic sensitivities below 30%, with sensitivities at or near 0% the first 48 hours of infection, using polymerase chain reaction (PCR) test positivity as the gold standard. Reliance on tests with low sensitivity could paradoxically increase transmission risk through false assurance. Furthermore, widespread testing has substantial direct and indirect costs, while its effectiveness for diminishing COVID-19 disease burden or improving overall community health is unclear. Because benefit has not been demonstrated with high-quality evidence, we argue against 1. The continued recommendations for and 2. Public funding of widespread community-based rapid antigen testing.
VERY IMPORTANT (Images of the actual SARS-CoV-2 virons) – Electron cryotomography of SARS-CoV-2 virions reveals cylinder-shaped particles with a double layer RNP assembly https://www.nature.com/articles/s42003-022-04183-1
IMPORTANT (Blood analysis) – Dark -Field Microscopic Analysis on the Blood of 1,006 Symptomatic Persons After Anti-COVID mRNA Injections from Pfizer/BioNtech or Moderna https://www.academia.edu/88220953/Dark_Field_Microscopic_Analysis_on_the_Blood_of_1_006_Symptomatic_Persons_After_Anti_COVID_mRNA_Injections_from_Pfizer_BioNtech_or_Moderna?email_work_card=title
IMPORTANT (Intramuscular inject often gets injected into veins) – Complications of injectable testosterone undecanoate in routine clinical practice https://pubmed.ncbi.nlm.nih.gov/25637074/
IMPORTANT (Intramuscular inject often gets injected into veins) – Tolerability of intramuscular injections of testosterone ester in oil vehicle https://pubmed.ncbi.nlm.nih.gov/7650133/
IMPORTANT (Intravenous injection of mRNA causes increased incidence of myocarditis) – Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model https://pubmed.ncbi.nlm.nih.gov/34406358/
IMPORTANT (Aspiration technique on vaccine intramuscular injection) – To aspirate or not to aspirate? Considerations for the COVID-19 vaccines https://link.springer.com/article/10.1007/s43440-022-00361-4
Syringe aspiration when vaccinating intramuscularly was not recommended before the pandemic due to the lack of conclusive evidence that it provides any benefit. However, in vivo evidence suggests that intravenous injection of mRNA vaccine can potentially lead to myocarditis, while introducing adenoviral vector to bloodstream can possibly result in thrombocytopenia and coagulopathy. These rare reactions were recorded in humans following the administration of the COVID-19 vaccines. Although the syringe aspiration may increase the level of pain at the injection site, it represents a simple technique to decrease the risk of vaccine introduction into the vascular system and potentially decrease the risk of severe reactions to mRNA and adenoviral vaccines. We are of the opinion that this cannot be disregarded if one considers that the COVID-19 vaccines will continue to be administrated globally in the form of initial and booster doses. Therefore, the aspiration when giving mRNA and adenoviral vaccines appears to be fully in line with the precautionary principle.
IMPORTANT (Combined flu and Covid-19 mRNA LNP injection) – Rational development of a combined mRNA vaccine against COVID-19 and influenza https://www.nature.com/articles/s41541-022-00478-w
IMPORTANT (Intravenous injection shock) – Induction of shock after intravenous injection of adenovirus vectors: a critical role for platelet-activating factor https://pubmed.ncbi.nlm.nih.gov/19953082/
IMPORTANT (SARS-CoV-2 similar to HIV inserts) – Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1
IMPORTANT (HIV Similarity) – COVID-19, SARS AND BATS CORONAVIRUSES GENOMES PECULIAR HOMOLOGOUS RNA SEQUENCES https://www.granthaalayahpublication.org/journals/index.php/granthaalayah/article/view/IJRG20_B07_3568
IMPORTANT (Nattokinase removes spike protein) – Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2 https://pubmed.ncbi.nlm.nih.gov/36080170/
IMPORTANT (Nattokinase inhibits viral infections) – Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro https://pubmed.ncbi.nlm.nih.gov/34271432/
Cardiac injury and troponin life expectancy
VERY IMPORTANT – 10-year survival outcome after clinically suspected acute myocarditis in adults: A nationwide study in the pre-COVID-19 era https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0281296
Results
Among 2,988 patients (51.0±16.9 years, 46.2% women), 362 (12.1%) were of complicated phenotype. Of these, 163 (45.0%) had died within 1 month. All-cause death at 30 days occurred in 40 (4.7%), 52 (4.8%), and 105 (10.0%) patients in the young-adult, mid-life, and older-adult groups, respectively. For 10 years of follow-up, all-cause death occurred in 762 (25.5%). Even in young adult patients with non-complicated phenotypes, excess mortality remained higher compared to the general population.
Conclusion
In hospitalized patients with clinically suspected acute myocarditis, short-term mortality is high both in young and older adults, particularly those with comorbidities and severe clinical presentation. Furthermore, excess mortality remains high for at least 10 years after index hospitalization in young adults.
IMPORTANT – Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres https://www.bmj.com/content/367/bmj.l6055
Results 257 948 patients had troponin measured during the study period. Analyses on troponin were performed using the peak troponin level, which was the highest troponin level measured during the patient’s hospital stay. Troponin levels were standardised as a multiple of each laboratory’s 99th centile of the upper limit of normal (ULN). During a median follow-up of 1198 days (interquartile range 514-1866 days), 55 850 (21.7%) deaths occurred. A positive troponin result (that is, higher than the upper limit of normal) signified a 3.2 higher mortality hazard (95% confidence interval 3.1 to 3.2) over three years. Mortality varied noticeably with age, with a hazard ratio of 10.6 (8.5 to 13.3) in 18-29 year olds and 1.5 (1.4 to 1.6) in those older than 90. A positive troponin result was associated with an approximately 15 percentage points higher absolute three year mortality across all age groups. The excess mortality with a positive troponin result was heavily concentrated in the first few weeks. Results were analysed using multivariable adjusted restricted cubic spline Cox regression. A direct relation was seen between troponin level and mortality in patients without acute coronary syndrome (ACS, n=120 049), whereas an inverted U shaped relation was found in patients with ACS (n=14 468), with a paradoxical decline in mortality at peak troponin levels >70×ULN. In the group with ACS, the inverted U shaped relation persisted after multivariable adjustment in those who were managed invasively; however, a direct positive relation was found between troponin level and mortality in patients managed non-invasively.
Conclusions A positive troponin result was associated with a clinically important increased mortality, regardless of age, even if the level was only slightly above normal. The excess mortality with a raised troponin was heavily concentrated in the first few weeks.
IMPORTANT (Micro-contaminents in vaccines) – New Quality-Control Investigations on Vaccines: Micro-and Nanocontamination https://img1.wsimg.com/blobby/go/85b53a53-5d37-4c08-a45f-200f105a1916/downloads/EXH%206%20Gatti%20IJVV-04-00072.pdf?ver=1697685887512
IMPORTANT (Sleep and antibody response) – A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination https://www.cell.com/current-biology/fulltext/S0960-9822(23)00156-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982223001562%3Fshowall%3Dtrue
IMPORTANT (Vax versus unvax outcomes worse in vaccinated children) – Analysis of health outcomes in vaccinated and unvaccinated children: Developmental delays, asthma, ear infections and gastrointestinal disorders https://pubmed.ncbi.nlm.nih.gov/32537156/
IMPORTANT (Vax versus unvax outcomes worse in vaccinated children) – Health effects in vaccinated versus unvaccinated children, with covariates for breastfeeding status and type of birth https://www.oatext.com/health-effects-in-vaccinated-versus-unvaccinated-children-with-covariates-for-breastfeeding-status-and-type-of-birth.php
IMPORTANT (Immune response dysregulation) – The dietary sweetener sucralose is a negative modulator of T cell-mediated responses https://www.nature.com/articles/s41586-023-05801-6
VERY IMPORTANT (Breakdown of virus RNA seen) – Infectious RNA transcribed in vitro from a cDNA copy of the human coronavirus genome cloned in vaccinia virus https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-6-1273
VERY IMPORTANT (Analysis of SARS-Cov-2 protein sequence) – Direct RNA nanopore sequencing of full-length coronavirus genomes provides novel insights into structural variants and enables modification analysis https://pubmed.ncbi.nlm.nih.gov/31439691/
Discriminatory Attitudes Against the Unvaccinated During a Global Pandemic https://www.nature.com/articles/s41586-022-05607-y
Outcome Reporting Bias in COVID-19 mRNA Vaccine Clinical Trials https://www.mdpi.com/1648-9144/57/3/199
Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis https://pubmed.ncbi.nlm.nih.gov/32721533/
Informed consent and trial prioritization for human subject research during the COVID-19 pandemic. Stakeholder experiences and viewpoints. https://www.medrxiv.org/content/10.1101/2022.10.31.22281754v1
Time intervals between COVID-19 cases, and more severe outcomes https://www.medrxiv.org/content/10.1101/2022.10.31.22281769v1
Inherent Defender Against SARS-CoV-2? PLSCR1 Keeps COVID-19 Out https://www.trialsitenews.com/a/inherent-defender-against-sars-cov-2-plscr1-keeps-covid-19-out-b1519706 Published Nature https://www.nature.com/articles/s41586-023-06322-y
Nursing Home Residents Faced Highest Risk for COVID-19 Death, Yet Accessed mAbs/Antivirals Far Less https://www.trialsitenews.com/a/nursing-home-residents-faced-highest-risk-for-covid-19-death-yet-accessed-mabsantivirals-far-less-d34f37e5 Published JAMA: https://jamanetwork.com/journals/jama/article-abstract/2807529
BIOLOGICAL RHYTHMS IN COVID-19 VACCINE EFFECTIVENESS https://www.medrxiv.org/content/10.1101/2022.10.31.22281719v1
Effect of SARS-CoV-2 vaccine on the breastmilk antibody response among lactating healthcare workers https://www.jimmunol.org/content/206/1_Supplement/30.15
Antivaxers are a global menace who must be defeated (Times Hit Piece – Saving here for reference of vitriol and misinformation) – https://archive.ph/2tblk